After website limitations forced me to begin restructuring what remains a work in progress that mitigating circumstances forced me to slap together than prematurely release what is more along the lines of a poorly structured yet beautifully organic example of learning processes involved in a rough draft notes page – To avoid butchering it any further I’ve decided to abandon it whilst working on a refined variation.
Hopefully it will allow me to replace some of what I deleted to make room to serve as a convenient easily accessible source of reference material.
This publication is an extension of Universal Asylums unauthorised experimental research Metabolic Implications of "Psychedelics / Forbidden Fruit" upon DRUG Saturation regarding the critical humanitarian and ecological significance of N,N-Dimethyltryptamin(e/ium) (DMT/DMT+) and similar maliciously over-regulated substances. Such research, initially insipred over a decade ago is directly connected to one two extensive individual yet increasingly interconnected portfolios of intellectual property steming from a professionally informed acidemic foundation of a Bachelor of (WTF's a) Social Work(er - A Brief Introduction). The 2nd portfolio initially inspired early 2008 is associated with Universal Asylums uncontested claim to its One World leaderless System of Governance having withstood Federal investigation concluding with neutrality after declaring Universal Asylum several years ago. Although actively seeking to advance understanding the interrelationships between humans and their ecological context which is complimented by invaluable relevant lived experience is vital to my professional capacity - I never anticipated this would include an ethical responsibility to independently undertake medical experiments into something of critical enough significance to require attempting to wrap my head around quantum scale biophysiology.
The scientific literature covered in recent months has increased previously raised concerns over existing primitive governments and corporate elite particularly the WHO & UN who's active role in the overregulation of scientific research into such substance inspired Universal Asylum's consideration of Bioterrorism Intervention. Despite advocating for Ayahausca as a viable Covid19 treatment I took the vaccine to ease mums mind thinking it wouldn't do any harm. Despite rarely affected by viruses throughout my life and 3 vaccines Covid made me about as sick as when bitten by a redback spider. Of course the one dose of Ayahausca in the fridge releaived all sysptoms as did Psilocybin mushrooms. It's hard to know what caused the rare Spontanious Coranary Arterial Discetion (SCAD) Heart Attack at 40years old. However, I would have been far better with 2more doses of Ayahausca which miraculously healed 8-9mths of chest pain from the SCAD when I finally got the courage to take it. Although getting off track such litrituare includes scientifically recognised evidence to support such claims
In whats claimed to be the most comprehensive neurotransmitter atlas published by Wang et al (2024) covers in great detail the overwhelming evidence of an "unknown neurotransmitter" critical to cummunity health. At present available information indicates that N,N-Dimethyltryptamin(e/ium) remains the primary suspect of a list of a blatantly obvious tho typically misunderstood group of potential champions likely to include variation in pros and cons for different people under different conditions. Overregulation of such critical forms of nutritional support has retarded human immune sustems leaving resulting in often almost complete dysfunction or significant dysregulation specifically in relation to our vulnerability to RNA viruses causing genetic deterioration and viral mutation. Unfortunatly, circumstances forced the premature production and release of numerous publications associated with complex heavily interconnected ongoing professional duties of critical social and ecological significance. Therefore I'm currently working to refine this publication which was slapped together and prematurely released due to the pressure of mitigating circumstances and sub-sequentially initially provided a poorly structured organic example of learning an entirely knew language prior to the website limit forcing me to hack it up. In the mean time I will leave embarrassingly underdeveloped work up whilst refining it's structure and content.
As previously hypothesised in an over-simplictic manner, N,N-Dimethyltryptamin(e/ium) s Hydrogen Bond Count (PubChem 2004) and the composition of water (Khan YS etal, 2024) is the only plausible means of completing the conductive circuitry to support what I described as Generalised Hyper Cellular Divergence, Intracellularly, Extracellularly and Transcytosis capable of the results of Universal Assylums medical experiments. The oversimplified spectrum between Hyper & Hypo Cellular Divergence failed to take into account factors such as cellular fatigue at variable rates across cell groups and individual cells however served it's purpose in introducing the concept. Expanding upon this the following haphazardly explores the most significant charactoristics of (N,N-Dimethyltrypt(amine/aminium) (DMT/DMT+) and it's fundamental interrelationships with l-Tryptophan, Serotonin & Brønsted Acid Bondage nature of this in relation to the basic biophysiological actions necessary to facilitate π-systems, Quantum-tunneling, complete reversible hydrolytic splicing and coevolution of Group II Introns and RNA Viruses.
In providing a breif summery leading into deeper analysis. Acording to Liang et al (2016) T cells, particularly CD4+T helper cells Th1 and Th17 and Dendritic cells are the most potent antigen-presenting cells and play a critical role in supporting innate and adaptive autoimmune system functionality. Opioids are recognised to cause major disruption to the CNS system including neuro-inflamation, dis-regulation of immune systems with significant impacts regulatory T cells, particualrly CD4+ T, Th17 and Dendric cells and including anti proliferative, cellular exhaustive and pro-apoptotic features (Plein & Rittner 2018) with RNA gene sequencing confirming their impacts on gene expression (Mikati 3023 & Sacerdote 2013). In human bone marrow, δopioid receptor mRNA express at a low level in immature dendritic cells, conversely, at a high level in mature dendritic cells which is an area of congestion which is particularly painful under “regular” conditions. Whilst frequently describe as immune-modulators it would appear more accurate to state that available evidence suggests that opioids cause cellular dis-regulations with various pros and cons under different conditions. Chronic inflammatory diseases are the most significant cause of death in the world. The World Health Organization (WHO) ranks chronic diseases as the greatest threat to human health (Pahwa R, et al,. 2023). A balanced combination of pro-inflammatory and anti-inflammatory mechanisms would facilitate viral clearance and immunity to reinfection, with minimal damage to host tissues (Rouse & Sehrawat). DMT and similar substances are scientifically recognised as activating particularly CD4+T helper cells Th1 and Th17 and Dendritic cells, supporting cellular proliferation, regulation of inflammatory systems with antiviral, anti tumour, anticancer and neuroregenerative actions (Szabo et al 2014, Szabo 2016 & Frecska 2016 & Rudin 2023).
In the same publication I also proposed symbiotic coevolutionary relationships between DNA and RNA viruses of multicellular lifeforms such as humans, interconnected to complex metabolic processes collectively contributing to healthy epigenetic coevolutionary interrelationships (Parker, M 2024). There are no shortage of scientists questioning the evidence of intimate symbiotic coevolutionary interrelationships between pathogens such as bacteria and viruses and immune systems (Van Blerkom 2003). According to Simmonds., Aiewsakun & Katzourakis, (2019) rates for DNA and RNA viruses of any configuration were remarkably similar for between 100 million to 1 billion years. ”Infection of the same host over tens or hundreds of years or perhaps even millennia may drive the evolution of each host-adapted virus to evolutionary stasis — an optimized genome that is maximized in those aspects of its fitness that maintain infections in the host population”.
Broecker & Moelling (2019) provide an important reminer that "life on Earth started with the smallest known autonomously self‐replicating catalytically active entities, the ribozymes, which consist of noncoding circRNAs with information solely based on structure. Especially, the ribosomes suggest that ribozymes preceded prokaryotes because they supply the protein synthesis machinery in all forms of cellular life.47 Possibly, viruses, or more specifically viroid‐like agents, may have been among the first biological entities.” To add to that equation I would like to add H2O and DMT/DMT+ as the major micro-species fitting the profile of the “universal ancestor” of “the biological tree of life” played a significant evolutionary role prior to the emergences of Pangea and ecological dicersity (PubChem 2024 & LibraTexts 2024). Severing Mankinds critical coevolutionary interrelationship with DMT is the most significant factor Science consistently overlooks in consideration to the neolythic revolution [52, 53, 54].
According to Clair, A., et al (2019) “reverse splicing” is an essential activity that allows group II introns which are considered to be extremely old, likely first evolving in bacteria with other ribozymes in the primordial “RNA world - to colonize new genomic DNA locations through retrotransposition. Comparing the branched splicing pathway and hydrolytic splicing pathways performed by group II introns and the spliceome outlined in Fig. 1 of the article - the process of hydrolytic splicing which is described as linear is incomple. Quote Fig. 1. Splicing pathways performed by group II introns and the spliceosome. A) Branched splicing pathway. The bulged adenosine nucleotide attacks the 5′ SS in the first step, resulting a free 5′ exon and a lariat-3′ exon intermediate. The 3′-OH of the free 5′ exon attacks the 3′ SS in the second step to yield ligated exons and lariat intron. B) Hydrolytic splicing pathway. The 5′ SS is attacked by a water molecule in the first step, resulting in a free 5′ exon. The second step proceeds as in the branched splicing pathway to yield ligated exons and linear intron.
Figure 1 (Clair A, et al., 2019)
The first two steps are identical as branced splicing though the biopysiological catalysts involved in the first and third steps of branced spliceing depicted in A) aren't all together clear. With hydrolytic splicing (without DMT/DMT+ the first step involves a water molecule or hydroxide ion attacking and freeing the 5′ exon, the free 5′ exon subsequently appears to have an attempted hydroxide to attack the 3′ exon splice site which fails to lariat the free 3' intron. I'm new to biophysiological equasions or more so the new language which appears very deliberately set up to prevent science from firureing this one out. In my head presumably having used one hydrogen and one oxygen molecule in the hydroxide attack to achieve the first step, the second step would be more appropriately marked H (rather than HO) for the single remaining Hyrogen molecule which might be attracted to the 3′ exon splice site but unable to do much more than jizz in its face.
Alternately all evidence suggests that DMT(+) is fully equipped to facilitate far more powerful precision quantum scale actions capable of lariat 3' exon and completing process of hydrolytic splicing and reverse transcripts. This is likely to involve complex combinations of Carbon, Nitrogen, Hydrogen, Oxygen bonds and/or unteractions to neautralisesvarious forms of energy until they are required to serve purposes of greatest priority at any point in time.
Leading into attemping to back the most important aspects of that up with scientific litriture I've chuched a few quotes in to provide context. According to Melissa A., Et al., (2019) "RNA splicing is a complex and dynamic process by which protein coding sequences (exons), split within the genome by intervening non-coding regions (introns), are reconstituted into a continuous, mature mRNA molecule by the macromolecular complex known as the spliceosome. Alternative splicing (AS), defined as the differential inclusion of coding or non-coding regions within a single mRNA, significantly expands the complexity of the cellular transcriptome and proteome, increasing genomic diversity from a limited population of protein-coding genes [[1], [2], [3], [4]]. Regulation of AS is controlled by two major interacting factors: (1) cis-regulatory sequences within the pre-mRNA that influence splice site selection and (2) their recognition by trans-acting factors, spliceosomal U snRNPs and RNA binding proteins (RBPs), that function to drive specific AS patterns. Precise modulation of AS “choices” is critical for proper gene expression in a developmental, spatio-temporal, and tissue-dependent manner [5,6]."
A great deal of scientific evidience has been published in recent years confirming interrelationships between Tryptamines, Tryptophan(s), Serotonin and possibly other amino acids casually accompanying one another to the service the cheack on on the spliceomes, etc. It was even mentioned Tryptamine and Tryptophan were recorded entering a single cell together [48, 49]. Although a work inprogess and currently transfering the details to a seperate blog the countless combinations of chemical crossovers make them like quantum chemists capable of neautralising andcreating any conditions required. My interpretation of the live status of certain micro-species is taken literally which fits with the job description above and scientific evidence of complex combinations actions indicating certain levels of consciousness.
"Over 30 hereditary disorders attributed to the expansion of microsatellite repeats have been identified. Despite variant nucleotide content, number of consecutive repeats, and different locations in the genome, many of these diseases have pathogenic RNA gain-of-function mechanisms. The repeat-containing RNAs can form structures in vitro predicted to contribute to the disease through assembly of intracellular RNA aggregates termed foci. The expanded repeat RNAs within these foci sequester RNA binding proteins (RBPs) with important roles in the regulation of RNA metabolism, most notably alternative splicing (AS). These deleterious interactions lead to downstream alterations in transcriptome-wide AS directly linked with disease symptoms. This review summarizes existing knowledge about the association between the repeat RNA structures and RBPs as well as the resulting aberrant AS patterns, specifically in the context of myotonic dystrophy. The connection between toxic, structured RNAs and dysregulation of AS in other repeat expansion diseases is also discussed." The direct quotes above are the introduction and abstract of the unambiguously titled article "Repeat-associated RNA structure and aberrant splicing". In lay terms this could be interpreted as dysregulation of immune functions is fucking up genetic evolution both throughout the lifetime of the individual and on intergenerational planes contributing to over 30 diseases. Hypo isn't exactly an accurate prefix to dysfunctional Cellular Divergence within a complex system comprising of many inter-dependant components unable to function properly due to malnutrition. Interestingly "The extracellular matrix (ECM) has traditionally been thought of as a static protein network surrounding cells and tissues. However, the ECM has recently emerged as a highly dynamic system" (Sacher F, et al., 2021).
Healthy celular functioning is only possible if cells have everything they need to maintain health functional capacity to get to the right places to perform specific actions, in the right order and of the highest quality, efficiently throughout time. If, for example, an organism is deprived of nutrition or subject or for other reasons such as stress of congestion where certain roles are repeatedly poorly performed or are unable to be performed at all, patterns of sickness and gentic deterioration emerge. O’Brien, K, et al., (2020) makes reference to this in more technical terms "There are also reports of direct cell-to-cell extracellular vesicle transfer via tunnelling nanotubes for RNA delivery93,94,95. The current focus of extracellular vesicle uptake is on endocytic pathways, which may result in part from the difficulty in assessing fusion events. Extracellular vesicles may also remain bound to cell surfaces without internalization (Fig. 3), engaging in cell signalling and antigen presentation53. It is currently unknown whether cells control the interaction and uptake of extracellular vesicles depending on their subtype and/or physiological state.".
Kammoun et al (2023) in their study into "A new organic–inorganic hybrid, namely the [C12H17N2]2ZnBr4" which basically traps four N,N-dimethyltryptaminium molecules inside crystaline with zink and bromoid. This study provides a simple yet complex for me example of DMT(+)'s role in molecular bondage which confirms an optical absorption measurement of semiconductor nature, that the electrical properties of the material are heavily dependent on frequency and temperature, indicating a relaxation phenomenon and semiconductor-type behaviour which is confirmed in greater detail in a similar study involving (C12H17N2)2[CdBr4] by Arafet Ghould et al (2024). Considering Zink is only one of countless variables in zoological species such as Humans there is a fair chance that adding DMT to the equation is likely to not only facilitate but regulate all kinds of biophysiological actions beyond scientific understandings.
After attempting to wrap my head the baisic biophysiological processes of hydrogen bonding to articulate the complexities of interactions under different conditions associated with the above - it eventially occured to me to undertake further investigations into the MF of DMT+ (C12H17N2+). - the more I am able to comprehend the more that DMT fits the profile of the non-canonical monoamine neurotransmitter [7] countless scientists recognise is missing [48, 49] with enormous consequences for the health of everything on the planet. Coincidentally, it just happens to be one of a particular group of substances terrorist organisations such as the WHO & UN have gone to great lengths preventing scientific progress for over 50years [50]. By doing so they have bioweaponised Humans and countless species [51]. On that note, what have they done to out our immune systems and genetic evolution?
Whilst examining the previous scientific publications curios over how their research was approved and to double checking the MF I came across something very interesting. Under "Ontology" section listed "Outgoing" DMT+ is conjugate acid of DMT. Incoming, is opposite with DMT a conjugate base of DMT+ (Anon, et al,. 2023). Although DMT is aledgedly the "Parent" it seems more like a Tautomer of DMT+ where there is a cyclic relationship between DMT and DMT+ involving a Nitrogen/Hydrogen Atom which makes it difficult to tell who came first. In the same way as the 'Yin and Yang' or male and female, if we are even allowed to use such terminology in this fucked up cunt of a contemporary society. According to my interpretation of section 3.3.4 is tautomer of the Chebi User Manuel (2024) the above should be written as:
This debunks my earlier reference to DMT fucking H2O. However, remains in the same ballpark and confirming with my discomfort with earlier use of the prefix "Alpha" it is entirely possible that DMT and/or DMT+ are interactive equal oppositinal halves of the same whole which were quite possibly dormant or perhaps less agressively dry-fucking themselves or one another until things got nice wet, and otherwise feeling right, spawing what's evolved over billions of years into seeingly infinite phenomonal posibilities of life life on earth. Well, at least until their shitest decendents being humans, not viruses, eventially lost their way trying to control everything shortly into the neolithic revolution.
My initial identification of the Hydrogen bond between DMT and H2O was based on my interpretation of descriptions of hydrogen bonding from Anon et al,(2023) in terms of duel bonding of a significant nature. Which came after learning of N,N-dimethyltryptaminium Molecular Formula (MF) C12H17N2+ (DMT+) described as a major microspecies at pH 7.3 it is a conjugate acid of a N,N-Dimethyltryptamine MF C12H16N2 (DMT) With a Hydrogen Bond Donor Count of 2. DMT and DMT+ also have only one Covalently-Bonded Unit Count which is presumably H2O (Or is it?). DMT and DMT+ what are also highly "Canonicalized".
Anyways, such a cyclic interrelationship with Hydrogen (H) attoms fits with the actions necessary to facilitate reverse hydrolytic splicing - "an essential activity that allows group II introns to colonize new genomic DNA locations through retrotransposition [26]" (Clair A, et al., 2019).
However it's not as simple as merely reversing the hydrogen bond action between DMT and H2O as it also requires maintianing states of neutrality and selectivity of timing of active actions in either direction. The metals in (Kammoun, et al 2023) and (Arafet Ghould et al 2024) scientific research particularly Zink along side the energies, frequencies and other factors do a good job of raising variable in relation to one of countless interactive elements in relation to this point. The infinite biophysiological variables presumably required for harmoniously synchronised intracellularly and extracellularly to facilitate transcytosis without dysfunction not only requires conductivity that is reversible but equipped with the full spectrum of fundamental biophysiological elements arranged appropriately to facilitate complex cellularly specific actions of each and ever individual cells to support complex combinations of healthy collective cellular interactions.
DMT(+) have a rotatable bond count of three which I am unsure I understand at this point in time (Wicker & Cooper, 2016) or how it fits in relation to two Methyl groups attached to an N / NH+ Amine/Aminium Nitrogen Atom.
One of these includes CH3 (Methyl Radical) which is basically a Carbon (C) Atom linked central to Three Hydrogen (H) Atoms. CH3 is organic and Canonicalised with a "Mixtures, Components, and Neutralized Forms (MCNF) Count: of 53". This doesn't seem like much until digging a little deeper and finding Methyl Radiacl Ch3 cooccurences with H^ (Hydrogen) , C^^^^ (Carbon) and CH3+ (Methylium). Methylium has a MCNF Count: of 1767 both followed by way too much awesome shit to list (PubChem, 2024).
H3C has been a little trickier. Initially the closest match I could get serching H3C via PubChem was the gene "N-(2,4-dimethylphenyl)-2,2,2-trifluoro-N-[(E)-(3-methoxyphenyl)methylideneamino]acetamide" which "coincidentally?" performs countless fitting actions (PubChem, 2024). Although noteworthy should it later prove to be significantly associated, I tried breaking H3C down into individual elements in the following serches.
According to PubChem H on it's own comes up with one result H(.) (Hydrogen) which is canocalized and has a Formal Charge (FC) of 0. However, searching H3 comes up with 3 results H3+3 (FC: 3), H3+ (FC 1) and H3-3 (FC -3) all canocalized. Whilst C only comes up with one result C^^^^ (Carbon) which is canocalized and includes the following 25 Chemical Co-Occurrences in Literature: Nitrogen, Water, Oxygen, Hydrogen, D-Glucose, Sulfur, Phosphorus, Carbon Dioxide, Sucrose, Iron, Methane, Lithium, Nitrate, Acetate, Silicon, Silicon Dioxide, Gold, Butyric Acid, Copper, Ethanol, Phosphate Ion, Methanol, Hydroxyl radical, Platinum, Sodium Chloride. Carbon also, interestingly has a Gene Count of 5395 and 100 Chemical-Gene Co-Occurrences in Literature.
According to Warren (2014) a methyl group consists of three hydrogen atoms surrounding one carbon atom, symbolized as CH3 and are capable of attaching directly to DNA by forming a chemical bond with cytosine to form 5-methylcytosine.
Nian-Dong (2021) advises that Five- and Six-membered aromatic rings bearing a methyl group are important molecular fragments, as the methyl group can play a pivotal role in improving the biological activities due to its capability in modulating the molecular conformation as well as the physical and chemical properties.
Comparing "Amine"/"Aminium" being DMT/DMT+ suffixes of its N/NH+ citation.
Contrary to the chiral inversion known in amines, the stereoinversion in corresponding aminiums is considered highly unlikely because of a high reaction barrier. However, high-level quantum mechanical computations, indicate that in gaseous state as well as in the presence of single water molecule acting as a catalyst, and also in a water solvated environment - the reaction barrier is reduced making the aminium cation prone to inversion. Interestingly, in contrast to molecules with a carbon atom stereocenter, stereoinversion with a nitrogen stereocenter was observed as a three multi-step process with quite high, or perhaps particular, reaction barrier. Although "gas-phase stereoinversion in the aminium cation is predicted to be infeasible, even along the proton transfer pathway which involves significant quantum tunneling" (Kaur, Ramanpreet & Vikas,. 2017) - DMT(+) appears to be biophysiologically equipped to facilitate the precision femto-scale actions required to create such conditions in order to achieve the processes above involved in stereoinversion. It is also not only possibly but highly likely that this same three multi step process is required to lariat the intron and complete hydrolytic splicing.
This is strongly supported by evidence that the hydration of carbon-carbon triple bonds is an important and atom economic synthetic transformation (Geil, 2021) combined with DMT(+) being of live status and equipped with two methyl stemming from its "Amine / Aminium" Nitrogen atom branching with an A and B cation attached to a five membered aromatic ring including an NH atom and being attached to a Six-membered aromatic ring. Additionally, According to Dean, J., Liu, T., Huff, S. et al. (2019) indolethylamine-N-methyltransferase potentially supports DMT-independent actions such as methylation of sulfur-containing compounds, histamine, and selenium metabolism [7].
According to Kaur, Ramanpreet & Vikas,. (2017) "Asymmetry is the essence of life [1]. From the life-makingmolecules ‘amino acids’ (all having L-form) to the life sustaining molecules ‘carbohydrates’ (all having D-form), asymmetry is significant [2, 3]. Although the chiral molecules of carbon are exceptionally important, the molecules having chiral centre other than carbon such as nitrogen, phosphorus or sulfur have their own significance in various fields of science [4–8]."
Ju, Li, Li, Yan, Cui, Ma & Zhao (2021) provided a great simples introduction to the concept of aromatic rings with consideration of concept of π-systems and photoinduced structural planarization via the six sided aromatic ring. Although structured in a far more symetrical fashion that this affirmed what I envisioned of DMT(+) biophysiological capacity to fold and/or thread in upon itself whilst worm-holing information in either direction via quantum tunnelling.
Interestingly, there are many examples of related cyclizations of tryptamine and tryptophan under various conditions including temperature, microwave feuquencies and propargylic catalysts. These include the formation of pyrroloindoline structure which I believe are of potential relevance to π-systems (Dengiz, Cagatay. 2016, Blom, et al 2024 & Kale, et al 2024) and have been identified in Psychotria leaves (Li, et al 2011) indicating a biosymbiotic coevolutionary interrelationships between plants and humans. Kale, et al (2024) noted a cascade of interaction including the pyrrolidine ring opening, followed by intramolecular cyclization via C–N bond formation at reflux temperature to obtain pyrrolo[1,2-a]indole scaffolds.
"In principle, N-pyramidal amines with three different N-substituents should also be optically active if there is a thermodynamically predominated N-invertomer in the conformational equilibrium. But except some special cases such as aziridines [9, 10], azanorbornanes [11, 12], and some sterically hindered amines [13], the enantiomers in such type of molecules cannot be separated because of the well-known phenomenon referred as nitrogen inversion [10, 11]. This is because of the low energy inversion barrier possessed by such molecules. One of the most common reactions of amines is their protonation [14]. The fascinating thing about this reaction is that if the aminium salt generated has all four groups different, then the protonation can convert an optically inactive (racemic mixture) into the active one, unlike the respective amines, the ammonium cations cannot undergo rapid inversion. Such reversal of absolute configuration can have serious implications in the case of asymmetric drugs [15]"(Kaur, Ramanpreet & Vikas,. 2017). Of Course this fits with potential reconfiguration of DMT(+) from amine to aminium under the right conditions.
After countless rabbit holes gradually breaking down N,N-Di-Methyl-Trypt-Amin(e/ium) encountering a similar gene as with the second Metyl and at one point wondering if “Pt” was platinum suffixed to “Try” I eventually found “Tript” as an abbreviation for Tryptophan in relation to plants (Jacobs, 2021).
According to Stefano Negri, Mauro Commisso, Linda Avesani, Flavia Guzzo, (2021) The indole alkaloids tryptamine and serotonin are chemically defined as indolamines, comprising an indole backbone and an ethylamine side chain derived from the amino acid tryptophan. These compounds are widespread among all living kingdoms, from bacteria to higher eukaryotes, in which evolution has shaped different distributions and functions, representing a fascinating yet still largely unraveled aspect of biology (Mohammad-Zadeh et al., 2008; Ramakrishna et al., 2011). In most organisms, including plants (but not humans), tryptamine is formed by the decarboxylation of L-tryptophan. The reaction is catalyzed by TDC, a pyridoxal 5′ phosphate (PLP)-dependent aromatic L-amino acid decarboxylase (AADC) type II (Kumar, 2016). AADCs operate at the interface between the primary and secondary metabolism, and produce biogenic amines for the synthesis of specialized metabolites (Facchini et al., 2000).
Stefano Negri, Mauro Commisso, Linda Avesani, Flavia Guzzo, (2021) also adds "In the case of TDC, these specialized metabolites include the indole alkaloids. Plant AADCs show higher amino acid specificity and represent a monophyletic group, having probably evolved independently from a universal common ancestor."
Image: Khan & Farhana, (2023) + filters
The concept of a "Universal Ancestor" at the base "The Biological Tree of Life" depicted above has come up a few times since initially sighted in Khan & Farhana, (2023). But who is it? N,N-dimethyltryptaminium (DMTD+) is described as a “Major Microspecies at pH 7.3 & is claimed to be a conjugate acid of a N,N-dimethyltryptamine inspired the exciting of the basic transition between DMT/DMT+ being the two equal opposites of the one universal ancestor which could well be the case. Interestingly, L-Tryptophan (Zwtterion) (CHEBI:57912) is also described as a “Major Microspecies at pH 7.3" creates another possibility of in some way being a componant or othwerwise related to that.
Connsistent with neumerous examples previously mentioned examples, under certain controlled conditions “Tryptamine” in combination with l-tryptophan, strongly inhibits 5-hydroxy-l-tryptophan, serotonin, and indole-3-propionic acid strongly inhibit H+-dependent l-[3H]proline uptake into Caco-2 cells with inhibition constants (K(i)) of 0.9 to 6.1 mM. Uptake of l-[3H]tryptophan into Caco-2 cells on the other hand was not inhibited by l-proline (Metzner, 2005). This is described as not to be a carrier cellular function but in my interpretation in a nutural environment almost like the accomany one another presumably in a manner that neutralises bonds until required. Such observations are consistent with the work of Blom (2024) where pyrroloindoline framework commenced with protection of tryptamine and followed by many examples of related cyclizations of tryptamine and tryptophan, some of which were claimed unsuitable for tryptamines. This could also be interpreted as evidence of the audacicty of attempting to control something that available evedence strongly indicates has a far more advanced understanding life and successful interrelationship with just about everything on the planet life than humans do.
Cano & Lopera (2013) reckon "Antigen recognition by TCR induces the formation of several “TCR microclusters” that accompany the reorganization and approach of other membrane molecules and signaling proteins towards the contact zone with the DC. This contact zone between the T Cell and DC membranes is known as an immunological synapse and consists of a highly organized and dynamic molecular complex divided into three concentric zones known as the central, peripheral, and distal supramolecular activation clusters. The central region is composed of the TCR complex, co-stimulatory and co-inhibitory molecules, and co-receptors. These co-receptors are known as primary and secondary activation signals". The complex biophysiological composition of DMT/DMT+ and it's diverse canocalization makes substances of similar classes the only forseeably viable forms of nutrition capable of activating the full spectrum of such supramolecular activation across clusters as required for different purposes such as doing a better job at splicing in the right directions at the right places and at the right times.
Apologies for the following huge are quotes but I can't parraphrase them accurately. Therefore, I will start by highlighting and making comment as I can whilst learning the lingo. According to Claire, et al (2019) "Group IIC introns were later identified as a separate class based on their unique streamlined RNA structure. To date, group IIC introns have only been identified in eubacteria [32,38]. The main difference between these groups are the specific method of exon recognition, as each group uses a different combination of base pairing interactions to recognize 5′ and 3′ exons during splicing [32,33,[39], [40], [41], [42]]. Group IIC introns are the smallest class, missing significant portions of RNA sequencecompared to other classes [35,[42], [43], [44]]. Introns in this group are highly dependent upon the IEP for lariat forming splicing, suggesting that the reduction in RNA secondary structure complexity coincided with greater protein splicing dependence. Group IIC introns are also unique in how they decode the 5′ SS, replacing long contiguous stretches of base pairing found in IIA and IIB introns with a sequence independent stem loop structure [32,33,38,41,45]." This is interesting in terms of fitting with the hypothesis that humans relationship with DMT/DMT+ was severed throughout the Neolithic revolution.
"Early evidence using DEPC modification experiments discovered an interaction between domains II and VI, named η-η′, that was proposed to participate in structural rearrangements between the steps of splicing (Fig. 6a) [48,49]. Their model proposed that the η-η′ interaction between DII and DVI is disengaged before and during the first step of splicing, and would engage after the first step to cause a conformational change allowing catalysis of the second step [49]" (Claire, et al., 2019). I don't know if the η-η is a coinicidence and what the "N,N" in DMT/DMT+ stand for. However, regardless, this fits with my earlier hypothesis regarding the splicing processes.
"This conformational change between the splicing steps was attractive because it also explained why the rate of the reverse splicing reaction was slower than the rate of forward splicing [26]. Although this early evidence supported the importance of DII in group II intron splicing, DII was not seen as essential to group II intron structure and splicing functions until recently [49]. DII was often truncated in order to eliminate unnecessary flexible RNA structure to make crystallographic efforts simpler [48]. However, in 2014 it was discovered that DII of group IIB introns plays an essential structural role by acting as a central hub, docking four tetraloop-tetraloop receptor interactions (τ-τ′, θ-θ′, η-η′, and π-π′) [48]. In group IIB introns, DII is composed of a stem radiating from the central wheel and two stem loops, D2a and D2b, which coaxially stack on top of one another (Fig. 2). The D2a stem loop contains a tetraloop receptor that the GAGA tetraloop in DVI can dock into (Fig. 2) [48]. The D2b stem loop was also observed to form a contact known as π-π′, which docks a DII GCAA tetraloop into a tetraloop receptor immediately adjacent to the bulged adenosine in DVI (Fig. 6a). Due to the proximity of the π-π′ to the bulged adenosine first splicing step nucleophile, this interaction has important mechanistic implications [48]. Biochemical assays showed that these two interactions are essential for splicing and work together in order to anchor DVI in the core of the intron. Mutation of the π tetraloop in DII to an inert UUCG sequence resulted in accumulation of lariat-3′ exon intermediate and free 5′ exon during splicing, further suggesting that these interactions may play a role in the transition between step one and step two of splicing [48]. Disruption of both π-π′ and η-η′ interactions simultaneously lead to almost complete stalling of splicing after the first step [48] (Claire, et al., 2019). Once again fitting with my earlier hypothesis regarding the splicing processes being incomplete and the DMT/DMT+ offering a range of actions capable of completing this process.
The crystal structure shows that the π-π′ interaction occurs in close proximity to the bulged adenosine residue, allowing this interaction to control the positioning of the bulged adenosine in the active site (Fig. 6a) [48]. It is hypothesized that these interactions function synergistically in order to prepare for the second step of splicing. Engagement of the π-π′ interaction removes the first step lariat product from the active site while simultaneously moving the 3′ SS into the active site [48]. In contradiction to early models, no large scale reorientation of DII and DVI has been observed in crystal structures. Rather the η-η′ interaction remains engaged at all times, serving as a static anchor for DII and DVI. Interestingly, the η-η′ interaction is absent in group IIC introns and it is yet to be concluded whether this class of group II introns has a π-π′ interaction."(Claire, et al., 2019).
Fig. 6. Structural rearrangements of the group II intron active site before and after the second step of splicing (Claire, et al., 2019 )
A) The two stems of DII (blue) form a y-shaped structure and two tetraloop-receptor interactions with DVI (magenta), π-π′ and η-η′ shown boxed in cyan. The π-π′ interaction is located very close to the 2′-5′ lariat bond between DI(i) nucleotide G1 (green sticks) and the bulged adenosine of DVI (magenta sticks) [48]. Rendered from PDB: 4R0D.
B) The pre-second step crystal structure of the P.li.LSUI2 intron (PDB: 6CHR) shows how the active site is rearranged after the first step of splicing. The 3′ SS is docked into the active site 10 Å away from the metal ions and the 5′ exon 3′-OH nucleophile. The scissile phosphate junction at the 3′ SS is kinked towards the catalytic metal ions M1 and M2 (orange spheres) coordinated by DV (red). The γ′ nucleotide U622 of DVI (magenta) is flipped 180° away from the active site, breaking its interaction with the γ nucleotide A420 of J2/3 (blue). Nucleotide A586 (red) of J5/6 has taken the place of nucleotide U549 (tan) in the base triple below DV, U549 stacks underneath the nucleobase of the J2/3 nucleotide G421 (blue), and J2/3 nucleotide A422 has disengaged from the catalytic triplex [69].
C) The post-catalytic crystal structure of the P.li.LSUI2 intron (PDB: 4R0D) shows the conformation of active site components after the second step of splicing. The nucleobase component of the bulged adenosine (magenta sticks) is disordered and the 2′-5′ lariat bond is located approximately 20 Å from the active site. The J2/3 nucleotide A422 (blue) has disrupted the catalytic triplex by forming a base triple with nucleotides from J4/5 and J5/6 (Claire, et al., 2019).
Depending on the state and history of genetic degeneration reoccurring patterns in cellular fatigue, mutation and dysfunction are likely to occur at any given point of intracellularly, extracellularly and transcytosis under similar hypo congested conditions. Tracing what complex processes are going on in there on a picoscale during hyper cellular divergence it is tricky (Sun., Su & Jiao. et al. 2023).
According to Moya et al (2000) quasispecies theory and group selection models concur "the cloud or distribution of closely related mutants fulfills the three conditions that the latter imposed to consider a group as the target of selection. First, we are dealing with replicative entities whose population structure promotes fast genetic divergence (63). Second, the members of the quasispecies are intimately related (64). Third, the whole distribution of mutants should be considered as an individual instead of a group (64). In summary, objections and explanatory power of both theories can be exchanged. Once stated the formal equivalence between quasispecies theory and group selection models, the major problem to be solved is to gain experimental evidence in favor of a supra individual unit of selection. However, few experimental or field observations have been reported, and the issue is still highly controversial." In relation to experimental evidence supporting "the supra individual unit of selection" - I propose DMT/DMT+ is the most biophysiologically equipped to support healthy maintenance and synergistic coevolution of the 50-100 trillion cells of the human multicellular system and RNA viruses.
ATM.... It's alll a hack job from hereforth!!!
Serotonin(1+)
Serotonin(1+) is an ammonium ion that is the conjugate acid of serotonin; major species at pH 7.3. It has a role as a human metabolite. It is a conjugate acid of a serotonin.
Serotonin
Serotonin is a primary amino compound that is the 5-hydroxy derivative of tryptamine. It has a role as a human metabolite, a mouse metabolite and a neurotransmitter. It is a monoamine molecular messenger, a primary amino compound, a member of phenols, a member of hydroxyindoles and a member of tryptamines. It is functionally related to a tryptamine. It is a conjugate base of a serotonin(1+).
Outgoing
serotonin (CHEBI:28790) has functional parent Tryptamine (CHEBI:16765)
serotonin (CHEBI:28790) has role human metabolite (CHEBI:77746)
serotonin (CHEBI:28790) has role mouse metabolite (CHEBI:75771)
serotonin (CHEBI:28790) has role neurotransmitter (CHEBI:25512)
serotonin (CHEBI:28790) is a hydroxyindoles (CHEBI:84729)
serotonin (CHEBI:28790) is a monoamine molecular messenger (CHEBI:25375)
serotonin (CHEBI:28790) is a phenols (CHEBI:33853)
serotonin (CHEBI:28790) is a primary amino compound (CHEBI:50994)
serotonin (CHEBI:28790) is a tryptamines (CHEBI:27162)
serotonin (CHEBI:28790) is conjugate base of serotonin(1+) (CHEBI:350546)
Tryptaminium is an ammonium ion that is the conjugate acid of tryptamine arising from protonation of the primary amino group; major species at pH 7.3. It has a role as a human metabolite, a mouse metabolite and a plant metabolite. It is an ammonium ion derivative and a primary ammonium ion. It is a conjugate acid of a tryptamine.
Tryptamine
Tryptamine is an aminoalkylindole consisting of indole having a 2-aminoethyl group at the 3-position. It has a role as a human metabolite, a plant metabolite and a mouse metabolite. It is an aminoalkylindole, an indole alkaloid, an aralkylamino compound and a member of tryptamines. It is a conjugate base of a tryptaminium.
Chemical Roles
A molecular entity capable of accepting a hydron from a donor (Bronsted acid).
(via organic amino compound )
Biological Roles:
Any mammalian metabolite produced during a metabolic reaction in humans (Homo sapiens).
Any eukaryotic metabolite produced during a metabolic reaction in plants, the kingdom that include flowering plants, conifers and other gymnosperms.
Any mammalian metabolite produced during a metabolic reaction in a mouse (Mus musculus).
Any intermediate or product resulting from metabolism. The term 'metabolite' subsumes the classes commonly known as primary and secondary metabolites.
(via alkaloid )
Ontology:
Outgoing
tryptamine (CHEBI:16765) has role human metabolite (CHEBI:77746)
tryptamine (CHEBI:16765) has role mouse metabolite (CHEBI:75771)
tryptamine (CHEBI:16765) has role plant metabolite (CHEBI:76924)
tryptamine (CHEBI:16765) is a aminoalkylindole (CHEBI:38631)
tryptamine (CHEBI:16765) is a aralkylamino compound (CHEBI:64365)
tryptamine (CHEBI:16765) is a indole alkaloid (CHEBI:38958)
tryptamine (CHEBI:16765) is a tryptamines (CHEBI:27162)
tryptamine (CHEBI:16765) is conjugate base of tryptaminium (CHEBI:57887)
Incomming:
N,N-dimethyltryptamine (CHEBI:28969) has functional parent tryptamine (CHEBI:16765)
N-acetyltryptamine (CHEBI:55515) has functional parent tryptamine (CHEBI:16765)
N-methyltryptamine (CHEBI:28136) has functional parent tryptamine (CHEBI:16765)
baeocystin (CHEBI:139505) has functional parent tryptamine (CHEBI:16765)
luzindole (CHEBI:131788) has functional parent tryptamine (CHEBI:16765)
melatonin (CHEBI:16796) has functional parent tryptamine (CHEBI:16765)
norbaeocystin (CHEBI:139479) has functional parent tryptamine (CHEBI:16765)
serotonin (CHEBI:28790) has functional parent tryptamine (CHEBI:16765)
tryptaminium (CHEBI:57887) is conjugate acid of tryptamine (CHEBI:16765)
L-tryptophan zwitterion
CHEBI:57912
An L-α-amino acid zwitterion obtained by transfer of a proton from the carboxy to the amino group of L-tryptophan; major species at pH 7.3. Formula: C11H12N2O2,
Smiles: [NH3+][C@@H](Cc1c[nH]c2ccccc12)C([O-])=O
Outgoing
L-tryptophan zwitterion (CHEBI:57912) is a L-α-amino acid zwitterion (CHEBI:59869)
L-tryptophan zwitterion (CHEBI:57912) is a tryptophan zwitterion (CHEBI:64554)
L-tryptophan zwitterion (CHEBI:57912) is tautomer of L-tryptophan (CHEBI:16828)
Incomming:
L-tryptophan (CHEBI:16828) is tautomer of L-tryptophan zwitterion (CHEBI:57912)
Abbreviation: trp_L
Name: L-Tryptophan
Charged Formula: C11H12N2O2
Smiles: [H]N1C([H])=C(C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])[C@@]([H])(C([O-])=O)[N+]([H])([H])[H]
Virtual Metabolic HUman Website Accessed: August 7 2024
Brønsted base
CHEBI:39142
A molecular entity capable of accepting a hydron from a donor (Brønsted acid).Outgoing :
Brønsted base (CHEBI:39142) is a acceptor (CHEBI:15339)
Brønsted base (CHEBI:39142) is a base (CHEBI:22695)
Incoming:
organic amino compound (CHEBI:50047) has role Brønsted base (CHEBI:39142)
protophilic solvent (CHEBI:48359) is a Brønsted base (CHEBI:39142)
L-α-amino acid zwitterion
D-tryptophan zwitterion
CHEBI:57719
Zwitterionic form of D-tryptophan having an anionic carboxy group and a protonated α-amino group; major species at pH 7.3.
D-tryptophan zwitterion is a Tautomer of D-tryptophan
Outgoing
D-tryptophan zwitterion (CHEBI:57719) is a tryptophan zwitterion (CHEBI:64554)
D-tryptophan zwitterion (CHEBI:57719) is tautomer of D-tryptophan (CHEBI:16296)
Incoming
D-tryptophan (CHEBI:16296) is tautomer of D-tryptophan zwitterion (CHEBI:57719)
tryptophan zwitterion
CHEBI:64554
An amino acid zwitterion obtained by transfer of a proton from the carboxy to the amino group of tryptophan; major species at pH 7.3.
Outgoing
tryptophan zwitterion (CHEBI:64554) is a amino acid zwitterion (CHEBI:35238)
tryptophan zwitterion (CHEBI:64554) is tautomer of tryptophan (CHEBI:27897)
Incoming
D-tryptophan zwitterion (CHEBI:57719) is a tryptophan zwitterion (CHEBI:64554)
L-tryptophan zwitterion (CHEBI:57912) is a tryptophan zwitterion (CHEBI:64554)
tryptophan (CHEBI:27897) is tautomer of tryptophan zwitterion (CHEBI:64554)
Tryptophan
Schoch et al (2020)As a central resource utilized by all major public sequence databases in the International Nucleotide Sequence Database Collaboration (INSDC; 1; http://www.insdc.org), the National Center for Biotechnology Information (NCBI) Taxonomy plays a vital role in structuring communication concerning all forms of life on Earth. Association of the correct organismal names with genetic and genomic data is foundational to nearly every aspect of biomedical, agricultural and ecological research. Accurate taxonomy is a crucial link between natural history and experimental science (2) and essential to investigation of phenomena related to human welfare such as emergence of pathogens, dispersal of invasive species, loss of biological diversity and climate change.
The NCBI Taxonomy consists of a single, hierarchically arranged list of organismal names across all domains of life. These names are correct, current and valid according to the best authorities within the separate taxonomic disciplines and codes of nomenclature. The NCBI Taxonomy also contains numerous informal names existing outside of the codes of nomenclature. The classification used is phylogenetic, to the degree feasible, reflecting our current understanding of organismal relationships and is regularly updated to reflect new information
Schoch, CL, Ciufo, S, Domrachev, M, Hotton, CL, Kannan, S, Khovanskaya, R, Leipe, D, Mcveigh, R, O’Neill, K, Robbertse, B, Sharma, S, Soussov, V, Sullivan, JP, Sun, L, Turner, S & Karsch-Mizrachi, I, NCBI Taxonomy: a comprehensive update on curation, resources and tools, Database, Volume 2020, 2020, baaa062, https://doi.org/10.1093/database/baaa062
Additionally, Unversal Asylum offers a global system capable of facilitating a biophysiologically centred approach to future scientific evolution informing the transition to a leaderless system of governance designed to maintain social stability whilst efficiently adapting to the rapidly evolving needs of society and our ecological interrelationships throughout time. As science is currenly bias due to the nature of outdated economic and political structures I have incorporated two specifically targeted reseach designs including the unorthorised experimental medical research model underpinning this publication and an animal model to help get science back on track and kick start a global survalience people keep advocating for designed to protect collective interests from viruses and the corporate elete from manipulating science and primitive systems of governance to achieve unethical objectives.
Potential Applications and shit
Whilst this offers a number of medical applications off the top of my head it is of far greater significance in supporting the health beinifits of DMT as a regular component of healthy diet as raised in N,N-Dimethyltryptamine (DMT) & Other "Forbidden Fruit" - Central Nervous System Specific Nutrients. Although limited due to storage the blood syrum and urine samples pending analysis are of potential value to this. Universal Asylums research models are also of value to gaining future samples under more advanced clinical conditions.
Until recently I have assumed increasing the power and efficiency of immune fucntion made DMT unsuitable for transplant reciptients in terms of rejecting donor organs. However, as my understanding advances of of the actions involved in facilitating this it also has potential therapeautic value in the genetic intergration of organ transplants.
Immuno and gene therapy of various forms also become a possibility as far as intorducing viral, bacterial or specific genetic material whilst under the influence of DMT in clinical settings either as a form of immunisation or the treatment of rare conditions. Obviously this will require clinical testing. However, I am far more confident about the immunisation of viruses given my experience with Ayahausca in treating Covid19 and bacterial infections such as sepsis. The latter is certainly worthy of consideration of those in such fields should they ever be allowed to undertake clinical research into the actions of DMT and similar substances.
To be continued or refined...
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